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Daily supplementation with Urolithin A may help support immune fitness by promoting mitochondrial health. Mitopure targets key drivers of immune aging, namely by increasing the number of early-responding immune cells, improving mitochondrial function in these cells, and supporting their energy metabolism — all of which support immune fitness.

Taking 1000 mg Mitopure daily for six weeks may enhance performance and recovery markers by improving aerobic endurance and countermovement jump height while preserving antioxidant status. This can provide a competitive edge for young male soccer players in training season.

Taking 1000 mg Mitopure daily for four weeks may enhance performance and recovery markers by reducing perceived effort and creatine kinase levels post-exercise. This can provide a competitive edge for athletes during high-intensity training, allowing them to train harder and recover more quickly.

UA produced a robust anxiolytic effect in high-anxiety rats without altering behavior in low-anxiety models. These findings position UA as a mechanistically supported intervention in preclinical models of heightened anxiety and provide systems-level insights into how mitochondrial pathways interface with synaptic function and circuit regulation in anxiety states.

Mitochondrial dysfunctions are common hallmarks in human cardiomyocytes upon heart aging and in chronic conditions. Preclinically, the post-biotic and mitophagy activator, urolithin A (UA), reduced both systolic and diastolic cardiac dysfunction in models of natural aging and heart failure. In humans, UA supplementation for 4 months in healthy older adults significantly reduced plasma ceramides clinically validated to predict CVD risks.